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It is prescribed off-label based on clinician judgment and emerging research

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On the one hand, mutant p53 can suppress the expression of apoptosis-related genes (such as Puma), helping tumor cells evade the apoptosis induced by chemotherapeutic drugs

The above results indicate that in the ovaries, CXCL10 can bind to IL18R1 to induce downstream AKT FOXO3A activation, which subsequently promotes the transcription of genes for PMF activation (Fig