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Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features

The mechanisms of the protective effect of quercetin could be the rebalancing of the antioxidant system and the modulation of renal biomarkers (Rahdar et al., 2021)

doi: 10.1146/annurev-animal-020518-115206 30 ClarkK.PorterN.RebeloL.GuyaderJ.LeeC

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49 Elevated inflammatory factors in T2D such as IL-6 and interferon- (IFN-) cand bind to their receptors, activate JAK2/STAT3, subsequently upregulates the expression of suppressor of cytokine signaling 3 (SOCS3), which inhibit IRS-1 cascade