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In this context, the application of advanced in vitro models, such as three-dimensional (3D) cell cultures and organ-on-chip systems, deserves particular attention

This strategic combination embodies an emerging paradigm in regenerative biology research: that carefully selected multi-component formulations can achieve synergistic effects exceeding those of individual agents by simultaneously optimizing multiple complementary pathways essential for tissue repair

10.1016/S0306-4522(96)00434-4 59 LarsenP