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In a majority, no treatment may be necessary, and the healthcare provider may undertake a wait and watch approach The prognosis of Melanotic Macule is excellent with appropriate treatment

In the ATTAIN-1 trial of orforglipron, the most common adverse events were nausea (2133% depending on dose), constipation (2129%), diarrhea (2123%), vomiting (1324%), and heartburn

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Criswell DS, Booth FW, DeMayo F, Schwartz RJ, Gordon SE, Fiorotto ML (1998) Overexpression of IGF-I in skeletal muscle of transgenic mice does not prevent unloading-induced atrophy