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Increased pain facilitates host withdrawal from the presence of noxious environmental stimuli (Adapted from figures by Allali et al (2020) & Receptor Promiscuity Numerous low affinity agonists for MRGPRX2 have been identified, resulting in speculation that this receptor may have evolved to have a promiscious ligand specificity that is necessary to evoke a protective response to a widespread variety of structurally different exogenous compounds produced by harmful plants, bacteria and parasites, as well as to recognize multiple endogenous mediators released by activation of host immune responses or sensory neurons, and amplify their responses (Figure 1) (Bader et al, 2014)

Indeed, even yeast only lacking Trx1 are severely compromised in their ability to synthesize DNA during S phase, resulting in growth arrest [92, 93]

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