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A controlled-release afamelanotide implant marketed as Scenesse is authorised in the UK for preventing phototoxicity in adults with erythropoietic protoporphyria

doi: 10.3389/fendo.2023.1200372

Patients with chronic kidney disease represent another important consideration, as traditional diabetes medications often require dose adjustments or become contraindicated as kidney function declines

When IL-6 acts on its receptor, it causes the phosphorylation of JAK2, leading to the phosphorylation of STAT3 and resulting in an increase in hepcidin expression