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These medications should only be prescribed according to their licensed indications, and evidence-based dementia prevention strategies include managing cardiovascular risk factors, regular physical activity, and a Mediterranean-style diet

497,498 In a streptozotocin-induced mouse model of type 1 diabetes, hyperglycemia-induced ER stress and ferroptosis are key factors contributing to myocardial I/R damage

A plausible scenario, then, looks like this: Phase 3 primary completion in late 2025, NDA submission in the second half of 2025, FDA filing acceptance and review initiation in early 2026, and a PDUFA (Prescription Drug User Fee Act) action date likely in mid to late 2026

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