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In addition, there is a hybrid receptor with components of the IR (one and one -chain) and the IGF-1R (one and one -chain), to which both insulin and IGF-1 can bind to, but with less affinity than that of their putative receptors [9]

The arcuate nucleus contains two opposing neuronal types: appetite-stimulating neurons (expressing neuropeptide Y and agouti-related peptide) and appetite-suppressing neurons (expressing pro-opiomelanocortin and cocaine- and amphetamine-regulated transcript)

The remaining missing data were subjected to kNN imputation, as this method has been proven to provide better performance, robustness, and an overall marginal type 1 error rate [30, 31], especially when the proportion of missing data across samples for a molecular feature is relatively low (as in our datasets, with only 11.6% of imputable variables)

Anthropometric and laboratory evaluations Patient weight and height were measured using a calibrated scale after patients removed their shoes and any heavy clothing