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doi: 10.1093/gerona/58.11.b970 34 CrucianiRDvorkinEHomelPMalamudSCullineyBLapinJet al
In rat experiments, a decrease in phylloquinone (vitamin K 1 ) and menaquinone-4 (a form of vitamin K 2 ) concentrations in extra-hepatic tissues was found in animals administered excess -tocopherol via the diet or by subcutaneous injection
The starting dose is 0.25 mg weekly for four weeks, increasing to 0.5 mg once a week
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