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This biased signalling where different agonists preferentially activate certain pathways may explain why some drugs exhibit stronger weight loss or glycaemic control than others

The regenerative evidence is overwhelmingly animal and cell-culture data

In order to adjust for confounders, the following covariate variables were selected as the independent variable: age, race, ethnicity, sex, BMI, history of chronic kidney disease (CKD), history of congestive heart failure (CHF), history of diabetes, history of gastric surgery, history of gastroparesis, whether bowel prep was used (e.g., underwent same day EGD-flexible sigmoidoscopy or EGD-colonoscopy), history of GLP-1RA use, and other medications known to contribute to delayed gastric emptying

The metabolic benefit is embedded in the weight management indication