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The speed of the development pipeline only adds to the challenge as GLP1 therapies are being used for approved indications beyond diabetes and obesity, including heart, liver and renal disease. With these evolving usage patterns, plan sponsors face a coverage dilemma defined by constant change and escalating financial exposure

Specifically, tirzepatide reduces high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6), both of which play central roles in cartilage degradation and osteoarthritis progression

Gallagher EJ, Sun H, Kornhauser C, Tobin-Hess A, Epstein S, Yakar S, et al

The delayed gastric emptying is intentional and therapeutic, but it may create an environment where stomach acid sits longer in your digestive tract

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