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Show up, challenge your muscles, and give them a reason to stay

I explain how dopamine regulates the balance between pleasure and pain, and what happens when this system becomes dysregulated, leading to addiction

In its discovery-to-proof-of-concept work, it activated both receptors in vitro , improved glucose-dependent insulin secretion and glucose tolerance in animals, and in early human studies lowered fasting glucose and body weight

Neither is magic

Shared decisionmaking is essential in scenarios such as borderline BMI thresholds, older age with frailty, complex polypharmacy, or psychiatric comorbidity, where benefitrisk calculus is individualized