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34 Moreover, the effects of endogenous gut- and brain-derived GLP-1 on energy balance seem to be independent of each other since CNS administration of physiologic concentrations of GLP-1 in rodent models has been shown to lower calorie consumption and induce weight loss, whereas peripheral GLP-1 infusion has no effect on energy food intake

Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1) medication

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Average weight loss during the nine weeks of tapering was 2.1%