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The vision loss is often most severe upon waking, as blood pressure tends to be lowest during sleep

The lack of pigmentation contributes to clinical and histologic misdiagnosis

Determining the right schedule for this therapy requires a personalized approach that considers several factors

After 72 weeks, patients who received up to 6 mg of orforglipron averaged a weight loss of 5.5%, those who received 12 mg averaged 7.8%, and those who received 36 mg averaged 10.5%, while the placebo group averaged just 2.2%