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MULTIDISCIPLINARY APPROACH TO RISK MANAGEMENT Effective cardiovascular risk assessment and management in MASLD require a collaborative model that integrates hepatology, cardiology, endocrinology, diabetology, and primary care, given the bidirectional relationship between liver disease severity, cardiometabolic comorbidities, and incident cardiovascular events [4,22]

GLP-1 agonists showed a higher reduction of HbA1c compared to placebo when including only obese patients, MD -0.60, 95% CI , -1.06--0.13

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Moreover, users who have already experienced a hypersensitivity reaction to tirzepatide, have gallbladder disease, or suffer from diabetic retinopathy should avoid tirzepatide