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TAC-operated mice also exhibited other features consistent with cardiac hypertrophy, including significantly increased heart volume (Figure 1F), as well as significant increases in heart weight relative to body weight or tibial length (Figure 1G)

Kwong LK, Mockett RJ, Bayne ACV, Orr WC, Sohal RS

How IGF-1 LR3 Works Reduced IGFBP binding The N-terminal extension and R3 substitution disrupt binding to IGF-binding proteins, keeping LR3 free in plasma rather than sequestered

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