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Appropriate Rate of Weight Loss Target: 0.5-1% of body weight per week maximum While GLP-1s can drive faster weight loss, slower is better for muscle preservation

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Beyond cancer, PRODH dysfunction is also linked to neuropsychiatric and metabolic diseases, including schizophrenia 65,66 , and hyperprolinemia type I 67 , reflecting its broader role in regulating mitochondrial redox balance and prolineglutamate neurotransmitter metabolism

The 143B and HOS cell lines were cultured in RPMI 1640 medium supplemented with 10% FBS and 1% P/S