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In vitro analysis should be followed by in vivo analysis of inflammatory, metabolic and atrophic effects (using Gcs-induced osteoporosis models, skin atrophy, myopathy, etc.) [8]

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Conversely, a finding of a CAC score of 100 AU or 75th percentile should reinforce efforts to find evidence-based LDL-Clowering strategies to reduce the ASCVD risk in such a patient