J Cachexia Sarcopenia Muscle 2025;16:e13677.ArticlePubMedPMC 112
When Phe levels are between 120 mol/l and 360 mol/l, no treatment is recommended, nevertheless, patients should be followed up until the age of 2 years to ensure that over time increase of protein intake does not result in increasing Phe levels [47, 48]
In low-risk healthy adults, the target should be set as part of a broader conversation about lifetime risk, not applied by default
However, we are seeing a high growth rate among those aged 31 to 50, particularly since 2022 onward
Evidence indicates that weight reduction not only alleviates pain but also enhances physical function, underscoring its critical role in breaking the vicious cycle between these conditions [41,42,43,44]