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This supplement (less than 1 g, up to thrice a day) showed improved onset of sleep, reducing nocturnal awakenings, and prolonging general sleep duration in older adults

Besides, this study provided insights into the mechanistic targets through which these agents exerted their beneficial actions, with highlighting the role of HMGB1/RAGE/JAK-2/STAT-3, PI3K/AKT/CREB/BDNF/TrkB, AMPK/SIRT-1/m-TOR, and PERK/CHOP/Bcl-2 cues, as possible contributors in ADHDs pathophysiology

N.de Graaf-HessA.WilmerM.van den HeuvelL.MonnensL.BlomH

L-arginine supplementation has also been explored for its potential to improve exercise tolerance in individuals with cardiovascular conditions