In adipose tissue, Dpp4 expression is related to adipocyte size, and both insulin and the inflammatory cytokine TNF- increase shedding of soluble DPP-4 from the membrane ( Dpp4 expression in the liver of mice prone to diet-induced obesity, independently of the degree of intra-hepatic fat accumulation ( Dpp4 expression is increased following exposure to high glucose (although not to insulin) ( Dpp4 (Figure 3)
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