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Prevalence in the US is 1:200 to 1:500 for homozygous mutations, seen mostly in Caucasians (highest in Scandinavian or Irish descent, lowest in African descent)

Also, there was no change in progression of disease on a Parkinson Disease Rating Scale

Yes, a lyophilized peptide will require reconstituting into an appropriate sterile laboratory solvent prior to further processing and/or study

For systemic or musculoskeletal targets, the peptide must absorb, survive first-pass metabolism or proteolysis in the portal circulation and liver, and reach the target tissue at an effective concentration

Vitamin B12 injections are a routine and effective treatment for deficiency or absorption problems