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Together, these systems synergistically safeguard cells against oxidative damage ( 3 The role of ROS in the formation of calcium oxalate renal stones It is now well-recognized that the injury to RTCs and subsequent formation of stones attributed to oxalate is due to the interaction of oxalate with the kidney generating ROS ( Studies conducted in vitro on cells, in vivo on animals, and clinical case studies have all shown that RTCs exposed to oxalate and/or calcium oxalate crystals generate excessive ROS, triggering oxidative stress and inflammatory reactions