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The primary endpoints were the change in body weight and the proportions of patients losing at least 5% and 10% of their initial body weight
The mechanism that makes these medications effective, slowing gastric emptying, is also what puts pressure on the lower esophageal sphincter and invites reflux
Effects of food restriction on fetal and placental growth and maternal body composition
But the exact mechanism by which this therapeutic effect sometimes becomes a pathological one, where delayed emptying crosses the line into permanent gastroparesis, remains unclear
There are still safe, effective options to use
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