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[41] Subsequent SUSTAIN trials (e.g., SUSTAIN-3 versus exenatide extended-release, showing 1.5% greater HbA1c reduction

Dysregulated metabolic pathways were identified

By extension, GLP-1 RAs through their modulation of microglial activation may replicate these neuroprotective dynamics in the optic nerve, offering a biological rationale for the observed reduction in glaucoma risk

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Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia-reperfusion injury