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Abbreviations Akt: Protein kinase B cAMP: Cyclic adenosine monophosphate CCR6: Chemokine (CC motif) receptor 6 CCL20: Chemokine (CC motif) ligand 20 ER: Endoplasmic reticulum FFA: Free fatty acid FoxO1: Foxrkhead box protein O1 Foxp3: Forkhead box P3 HE: Hematoxylin and eosin GLP-1: Glucagon-like peptide-1 GLP-1R: Glucagon-like peptide-1 receptor GLP-1RA: Glucagon-like peptide-1 receptor agonist HOMA-: Homoeostasis model assessment of -cell function HOMA-IR: Homoeostasis model assessment of insulin resistance IL: Interleukin IFN-: Interferon- LPS: Lipopolysaccharide NFB: Nuclear factor kappa-B NOD: Non-obese diabetic NTS: Nephrotoxic serum nephritis OGTT: Oral glucose tolerance test PA: Palmitate PBMCs: Peripheral blood mononuclear cells PI3K: Phosphoinositide 3-kinase ROR-t: Retinoid-related orphan receptor gamma-t T1DM: Type 1 diabetes mellitus T2DM: Type 2 diabetes mellitus Teffs: Effector T cells TGF-: Transforming growth factor- Th17 cell: T helper 17 cell TLR4: Toll-like receptor 4 TNF: Tumor necrosis factor Treg cell: Regulatory T cell References Alicic RZ, Cox EJ, Neumiller JJ, Tuttle KR