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Without trial data, this is speculative

Many of the cytokines involved in psoriasis signal through Janus kinase and signal transducer and activator of transcription proteins

At the same time, IL-6 will also have a pro-inflammatory role via trans-signaling where soluble IL-6 receptors can stimulate any cell type [141]

Bottom line: Both papers point to an impact in the ballpark of 0.5 to one percent of GDP in their main scenarios

Patients with pre-existing gastrointestinal conditions , including inflammatory bowel disease, should inform their prescriber before starting Wegovy, as baseline symptoms may complicate assessment of treatment-related effects