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Renal tubular epithelial-specific deletion of PRMT1 mice were generated by crossing floxed PRMT1 mice with Cdh16-Cre mice and wild-type littermates were used as controls

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93 In IPF, abnormally activated Wnt signalling is detected, which manifests as follows: significantly increased expression of Wnt1, Wnt7b, Wnt10b, FZD2, FZD3, -catenin, and LEF1 in the lung tissue, thereby promoting fibroblast proliferation and epithelial cell-mesenchymal transition, the pathological process of IPF

A randomized phase 2b trial examined the effects of the glucagon-like peptide-1 and glucagon receptor agonist cotadutide on kidney outcomes in patients with diabetic kidney disease