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Mu-opioid receptor desensitization: is morphinedifferent

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PAMAM and related dendrimers accumulate in injured brain regions and concentrate within activated microglia in many animal models, a property exploited for targeted therapy but one that also raises the possibility of cumulative dosing effects and sustained microglial stimulation (165, 166)

The nausea from oral semaglutide tends to be more frequent than from the injectable form because of higher local concentrations in the GI tract

This risk is further compounded by the presence of impurities in synthetic peptides [191]