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Metformin as a first-line treatment for type 2 diabetes, and Peters evolving interest in metformin as a geroprotective drug [22:00]

The astrocytes lose their ability to promote neuronal survival, become neurotoxic, block OLG differentiation, and enhance OLG death (Liddelow et al., 2017

By age 65, that reduction can reach 50 percent

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