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This review aims to summarize the evidence regarding the nephroprotective effects of glucagon-like peptide-1 receptor agonists (GLP-1RA) and tirzepatide and the putative mechanisms underlying the favorable renal profile of tirzepatide

Higher doses have demonstrated greater reductions in body weight, with some trials reporting significant results at 8 mg or 12 mg after several months of treatment

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The Phase 2 trial used 4-week intervals between increases, and groups that followed dose escalation had better tolerability than those started at fixed higher doses

MGST3 protein expression was strongly positive in both epithelial and stromal components of OMA tissues (Figs