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Patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMMs) offer more physiological insights but are limited by cost, long development times, and species-specific differences [40,41,42]

[DOI] [PubMed] [Google Scholar] 27.Koren G., Ornoy A

SLU-PP-332 is a synthetic small molecule agonist selectively targeting estrogen-related receptor alpha (ERR), a nuclear receptor known to regulate genes involved in mitochondrial biogenesis and oxidative metabolism

The speed at which alcohol reaches the small intestine determines peak BAC timing how quickly and how high blood alcohol rises