glp-1 and leg cramps Semaglutide Cramps: Causes, Management, and Prevention Does GLP-1 Cause Leg Cramps?

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In pulmonary arterial hypertension (PAH), specific studies using monocrotaline (MCT)-induced PAH models suggest that liraglutide acts through the NO/sGC/cGMP pathway, increasing NO release, activating soluble guanylate cyclase (sGC), and enhancing cyclic guanosine monophosphate (cGMP) synthesis

The GLP-1 medication may be reduced or discontinued while HRT continues at the same dose

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This is particularly beneficial for patients who experience severe side effects with standard dosing, as it allows them to continue treatment without compromising their comfort or safety