For related setmelanotide indications (Bardet-Biedl syndrome), Canadian health technology assessments published in 2023 estimated annual costs of approximately $294,000 per year for pediatric patients and $441,000 per year for adults at full dose

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Nature Medicine, 2024 Swedish national register cohort, n = 1,016,387 The proposed mechanisms include reduced neuroinflammation, improved insulin signalling in the brain, and potential effects on amyloid accumulation
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