In addition to lowering the levels of blood glucose, as shown in Figure 1 , GLP-1RAs have also been shown to have a positive effect on multiple human tissues
Clinical Considerations Disease-Associated Maternal And/Or Embryo/Fetal Risk Poorly controlled diabetes in pregnancy increases the maternal risk for diabetic ketoacidosis, preeclampsia, spontaneous abortions, preterm delivery, and delivery complications
Known risks include temporary digestive issues like nausea or constipation
Besides, the important role of other lipoxygenases such as 12- and 15-lipoxygenases in diseases have also been recognized, which promoting the development of specific inhibitors of these lipoxygenases [268, 269]
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