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As reported by Peng et al

Standard Protocol (Weeks 5-12) Daily Dose : 400 mcg subcutaneous injection Timing : Morning, fasted state preferred Frequency : Once daily Duration : 8-12 weeks continuous use The 400 mcg dose represents the optimal balance between efficacy and tolerability for most individuals

Delivering this novel human IGF-1 though eating lettuce is effective, easily delivered, and an attractive option for patients

It is classified as a triple receptor agonist for its capacity to simultaneously engage the glucose-dependent insulinotropic polypeptide (GIP) receptor, glucagon-like peptide-1 (GLP-1) receptor, and glucagon receptor a receptor profile that differentiates it from the single- and dual-receptor agonists more commonly evaluated in metabolic pharmacology research

doi: 10.3389/fnmol.2025.1553438 Received 30 December 2024 Accepted 03 March 2025 Published 18 March 2025 Volume 18 - 2025 Edited by Mazahir T