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These typically include: Nausea (most frequently reported) Diarrhea Vomiting Constipation Indigestion Abdominal discomfort Serious side effects While less common, there is a potential for serious adverse effects that require medical attention: Hypoglycemia (abnormally low blood sugar) Pancreatitis (inflammation of the pancreas) Hypersensitivity reactions Renal impairment Visual disturbances Gallbladder complications Tirzepatide works best with a healthy diet and lifestyle Weight loss medications like tirzepatide (Mounjaro and Zepbound) work best when paired with proper nutrition

They work by slowing stomach emptying, reducing hunger, and increasing feelings of fullness, which leads to lower calorie intake and weight loss

LRRK2 is a large multi-structural domain protein kinase present in the cytoplasm and associated with mitochondrial membranes (Mata et al., 2006)

See Supplementary Table 3 for qRT-PCR primer sequences