[118] Approved for weight management, GLP-1 RAs, such as liraglutide and semaglutide, are recommended for individuals with a BMI of 30 kg/m or greater or 27 kg/m with related comorbidities like hypertension
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It plays several important roles: Helping maintain healthy blood sugar levels after meals Supporting a feeling of fullness and satisfaction Regulating appetite and digestion When GLP-1 activity is healthy, it may help reduce cravings, support balanced energy, and contribute to gradual, sustainable weight management
This study (STEP-1 trial) demonstrated that participants using semaglutide lost a significant amount of weight, with approximately 39% of the weight loss attributed to lean mass , raising concerns about muscle preservation during GLP-1-induced weight loss
It also remains to be seen if this somewhat cheaper medicine will lead to more insurers covering the product.