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221,591 Crystal structures of both apo- and molybdate-bound forms of ModE 597 reveal that the molybdate binding to the C-terminal domain alters the relative orientation of the N-terminal DNA binding domains from each protomer, allosterically activating the ModE homodimer to bind DNA (Figure 21C)

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pregnancy and lactation warrant specialist oversight since megadose therapy is generally reserved for severe, documented deficiency that cannot be corrected by standard oral supplementation