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MECHANISMS AND PHYSIOLOGICAL EFFECTS OF GLP-1 RECEPTOR AGONISTS MECHANISMS AND PHYSIOLOGICAL EFFECTS OF GLP-1 RECEPTOR AGONISTS Molecular mechanisms Molecular mechanisms Glucagon-like peptide-1 (GLP-1) is an incretin hormone naturally secreted by the intestinal L cells in response to nutrient ingestion

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(Source: PMC / JCI, 2026) Mental health monitoring: If you experience new or worsening depression, anxiety, or thoughts of self-harm while on or after stopping a GLP-1, contact your clinician promptly

Ageing is also associated with a prominent decrease in the neurogenic potential reflecting functional asthenia of stem radial astrocytes

Review our complete guide to supplements to take with tirzepatide for a comprehensive list of what to consider alongside your GLP-1 medication