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pseudomallei infection, it is likely that a low GSH threshold exists for triggering the T6SS5 virulence program (cytoplasmic concentrations are in millimolar range even in diabetics) and that boosting GSH levels benefit the host more than the bacterium

Under this selective exogenous L-carnitine deficiency, we found profound embryonic lethality both in the gbh-1(ko) knockout allele as well as in the gbh-1(G283R) and gbh-1(G247Vfs*6) variants

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In some embodiments, the formulations or compositions described herein are not administered through the tympanic membrane