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With regard to long-acting GLP-1RAs, there are now four contenders (five if dulaglutide is included) with definite or probable cardiovascular benefit (Figure 1), but from these, as 2019 dawns and semaglutide is available to be prescribed in the UK, this GLP-1RA may well be the first choice to be considered

Microdosing semaglutide may help with improved patient tolerability and adherence by lowering the risk of these adverse events due to very small doses of semaglutide

The medication mimics the action of the naturally occurring hormone GLP-1 , which is released from the intestine in response to food intake

Anderberg RH, Richard JE, Hansson C, Nissbrandt H, Bergquist F, Skibicka KP