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The interaction of surface localised HLA-gliadin complexes with fellow T-cells also leads to the recruitment of immune system components including natural killer cells which have a destructive impact on the gut barrier through cytokine release (Smyth 2017)

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10.3389/fgene.2019.00435 60 HannanM

Bottom line is, neither the benefits nor the risks of the vast majority of these peptides have been scientifically proven in humans

Renal Impairment Methylene blue concentrations increased in subjects with renal impairment (eGFR 15 to 89 mL/min/1.73m 2 )