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The possible explanations for the higher insulin sensitivity in PWS could be the relatively lower visceral adipose tissue (VAT) and higher subcutaneous adipose tissue (SAT) than BMI-matched controls, as well as the predominant accumulation of subcutaneous fat in the trunk and proximal limbs, with a lower ratio of trunk-to-appendicular fat (167, 185, 186)

Immunofluorescence staining The tumor-bearing liver tissues from C57BL/6 mice were frozen section, and then the slices were permeabilized with 0.3% Triton X-100 solution for 15 min at room temperature

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The effect is gradual and sustainable because it works with your body's natural hunger signals rather than stimulating your nervous system like older weight loss drugs