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Diagnosis typically involves blood tests including full blood count (showing macrocytosis), anti-intrinsic factor antibodies (which are specific for pernicious anaemia), and sometimes anti-parietal cell antibodies

Yet, whether Rho/ROCK directly mediates TGR5 effects in vivo remains to be confirmed by additional experiments, such as in vivo gene knockout models and Western blot analysis of hypothalamic tissue [68]

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doi: 10.1038/s41586-022-04569-5 16 PanRGZhangQRAnthonySMZhouYZouXFCassellMet al

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