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Engineering of Kuma030: a gliadin peptidase that rapidly degrades immunogenic gliadin peptides in gastric conditions

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246,247 Apart from acetylation, lactate alters the anaphase-promoting complex (APC/C) by directly blocking the Small Ubiquitin-like Modifier protease (SUMO protease) sentrin/SUMO-specific protease 1 (SENP1) and stabilizing SUMOylation at two specific residues on APC4

This increased demand can potentially create relative deficiencies in these co-factors, even if their levels were previously adequate

Furthermore, Quan et al