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Consider supplementation in asymptomatic patients with risk factors (see Table 2: Patient Risk Factors Associated with Folate Deficiency below) consider supplementation

The background angiotensin-IV/AT4 literature it builds on is independent and intact (Wright & Harding 1995, PMID 7768321

The most comprehensive review to date, published in JAAOS Global Research & Reviews , reached the same conclusion: Although preclinical studies are promising, there is a current lack of clinical trials (Rahman et al., 2026)

But I went on it when weaning off Klonopin for this first time and it made so much of that hell easier