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During drug screening experiments for amlexanox, a drug used in the treatment of asthma and aphthous ulcers, it was discovered that amlexanox inhibits both IKK and TBK12 kinases and reduces body weight in diet-induced or genetically obese animals by increasing energy expenditure

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Although baseline and 6-month HbA1c values differed between groups, the magnitude of HbA1c reduction was not significantly different (Table 5)

Dehydration can cause muscle cramps, and Wegovy's gastrointestinal side effects, such as nausea, vomiting, or diarrhea, may increase the risk of dehydration

Proteomics readjustment of the Yarrowia lipolytica yeast in response to increased temperature and alkaline stress