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Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints

Accumulating evidence suggests that stress can activate an inflammatory response in the brain that may contribute to the risk of mental illness, depression, and other stress-related diseases (6, 7)

Indicatively, an in vitro study utilizing the BeWo cell line showed that synthetic cannabinoids can lead to apoptosis and mitochondrial dysfunction in placental cells, thus leading to disturbances in fetus health [38,39]