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Small and potentially non-representative sample sizes, a lack of mechanistic depth, reliance on non-specific markers, the absence of diagnostic metrics, limited focus on clinical translation, and the use of cross-sectional designs collectively restrict their generalizability and applicability

Advise patients to seek immediate medical attention if they experience any symptoms of serious or severe hypersensitivity reactions [see Warnings and Precautions (5.1)]

[PMC free article: PMC4608820] [PubMed: 26473736] 20

Early clinical trials of HS-10270 have shown positive results, including improvements in both glycemic control and body weight management

However, patients with ingestion of larger doses may present with more severe signs and symptoms [Table 23]